When it comes to treating hypoactive sexual desire disorder (HSDD) in women, two cures have risen to the forefront of modern medicine: Flibanserin (brand name: Addyi) and Bremelanotide (brand name: Vyleesi).
Both are FDA-approved medications to manage premenopausal women’s distressing low sexual desire. However, the question remains: which is the best choice for Flibanserin or Bremelanotide?
This article aims to unravel the differences between these two treatment options, comparing their efficacy, side effects, administration methods, and overall patient satisfaction. Read on!
Flibanserin: An Overview
Flibanserin is a non-hormonal medication believed to affect the neurotransmitters in the brain involved in sexual desire. Commonly known as the female viagra, it was approved by the U.S. Food and Drug Administration (FDA) in 2015 as the first-ever treatment designed explicitly for HSDD.
Features of Flibanserin
- Type of Drug: Flibanserin is a serotonin 1A receptor agonist and a serotonin 2A receptor antagonist.
- Administration: Taken orally once daily at bedtime.
- Efficacy: Several trials have shown a slight improvement in sexual desire and decreased distress associated with low sexual desire.
- Side Effects: Common side effects include dizziness, nausea, fatigue, sleepiness, and insomnia. Less commonly, low blood pressure and fainting may occur.
Bremelanotide: An Overview
On the other hand, Bremelanotide operates analogously to a naturally occurring hormone in the body. The FDA approved it in 2019, making it the second FDA-approved treatment explicitly intended for premenopausal women with HSDD.
Features of Bremelanotide
- Type of Drug: Bremelanotide is a melanocortin receptor agonist.
- Administration: It is an injectable medication taken subcutaneously (under the skin) in the thigh or abdomen at least 45 minutes before anticipated sexual activity.
- Efficacy: Studies demonstrate a small but significant improvement in sexual desire and decreased associated distress.
- Side Effects: Common side effects include nausea, flushing, injection site reactions, and headache. More serious side effects may include a temporary increase in blood pressure and reduced heart rate.
Flibanserin vs. Bremelanotide: A Comparative Analysis
When comparing these two medications, the decision often depends on individual patient preferences and lifestyle. The key points of contrast between Flibanserin and Bremelanotide are:
Dosage Schedule
Flibanserin is taken once daily at bedtime, regardless of whether sexual activity is anticipated, making it potentially more convenient for individuals with regular sexual activity. Bremelanotide requires more planning, as it must be taken at least 45 minutes before sexual activity and no more than once a day.
Administration Method
While Flibanserin is an oral medication, Bremelanotide is an injection. This may be a key consideration for individuals who prefer a specific administration method or are uncomfortable with injections.
Side Effects
Both medications come with potential side effects, but their specifics differ. Users of Flibanserin report sleepiness and possible fainting, whereas users of Bremelanotide have noted temporary increases in blood pressure and decreased heart rates.
Drug Interactions
Flibanserin cannot be taken with alcohol or within two hours of consuming alcohol as it may cause severe low blood pressure and fainting.
Women taking Bremelanotide should avoid it within 24 hours of using a drug with similar pharmacological effects due to potential additive effects on blood pressure.
Cost and Insurance Coverage
While the cost might not directly relate to health outcomes, it is crucial to consider. Currently, insurance coverage for the two drugs varies significantly, and patients should consult their policies to understand their coverage.
The retail cost of these drugs also differs, and factors like insurance coverage, available patient assistance programs, and individual pharmacies play a role in determining the final “out-of-pocket” expenses.
Which Is Better: Flibanserin or Bremelanotide?
Choosing between Flibanserin and Bremelanotide depends on how you take them, their side effects, their effectiveness, and your needs. Flibanserin is a daily pill, while Bremelanotide is an injection you use when needed. The one that works best for you depends on your lifestyle.
Both medications can improve sexual desire, reduce related distress, and work better in some studies. However, individual experiences vary.
Flibanserin may cause sleepiness, while Bremelanotide might temporarily increase blood pressure. Remember to consider each drug’s cost and insurance coverage, as they differ.
Final Thoughts
Both Flibanserin and Bremelanotide offer invaluable solutions for women struggling with HSDD. While these medications won’t work the same for everyone, they represent a significant leap forward in the medical community’s approach to women’s sexual health.
Your doctor can guide you on the best choice, ensuring you make an informed decision that aligns with your personal preferences and medical needs.
